"Factors Associated With Persistent Symptoms Following Mild Traumatic Brain Injury"

W. Frank Peacock, MD; Damon Kuehl, MD; Ramon Diaz-Arrastia, MD, PhD; Jake Vanlandingham, PhD; Martin Than, MD; Chad M. Cannon, MD; Adam J. Singer, MD; Nazanin Mirshahi, PhD; Justin Weppner, DO, MEd; Robert Gerwien, PhD

 October 2025 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2840299

Findings:

In this cohort study of 803 patients presenting at a median of 1.5 hours after an mTBI (Glasgow Coma Scale score ≥13), 9 characteristics were significantly associated with symptoms persisting for 30 days: female sex; elevated body mass index; mechanism of injury; a prior diagnosis of headaches or migraines, depression, or anxiety; and the presence of focal neurological deficits, headache, or multiple computed tomography scans at intake.